Accepted: 2025-05-08
Due to the high incidence risk of neonatal jaundice and the limitations of conventional monitoring methods, there is a clinical need for non-invasive dynamic jaundice detection devices. This study designed a wearable system for dynamic jaundice level and physiological parameter detection. The system includes a forehead-mounted wireless physiological signal collector, a Bluetooth communication host and a data analysis platform based on LabVIEW. The system uses the highly integrated MAX86916 optical sensor to synchronously collect four-channel photoplethysmography (PPG) signals, and obtains bilirubin, heart rate, and blood oxygen saturation data through signal processing. The nRF52832 microcontroller with Bluetooth Low Energy (BLE) protocol is used for wireless communication. The data is transmitted wirelessly to the Bluetooth communication host, and then uploaded to the LabVIEW program of the PC via USB for display and storage. To verify the functionality and performance of
the system, basic parameter tests, and comparative tests of each physiological parameter with commercial instruments were conducted in sequence. The device (13.5g, 41mm×29.7mm×15.1mm) can monitor continuously for 5 hours. The detection range of the bilirubin prediction model is 1~13mg/dL. Measurements demonstrated bilirubin, heart rate and blood oxygen were in strong agreement with standard instruments (p>0.05). And the maximum absolute errors for bilirubin, HR, and SpO₂ measurements were 0.97mg/dL, 1bpm, and 2.1%, respectively. Moreover, the system can sensitively track the decrease in heart rate after exercise and the changes in blood oxygen during breath-holding. The system demonstrates accurate monitoring of jaundice, heart rate, and blood oxygen levels. It integrates the advantages of lightweight design, wearability, multi-parametric detection, and non-invasive dynamic measurement capabilities. After further optimization, it is expected to be applied in neonatal clinical monitoring.