n order to solve the problem that partition application cannot be executed correctly when running ARINC653 partition operating system and application program on MPC750 processor hardware simulator provided by QEMU5.1.0, this paper carries out abnormal cause analysis, related technical research and problem code investigation. Based on the research of PPC simulator source code provided by QEMU, MPC750 processor documentation and ARINC653 operating system related code, by analyzing the abnormal printing information of the operating system, observing the modification of the memory status of the simulator, and testing the setting of the relevant status register of MMU, the QEMU code problem is located. The partition application can start and run normally under MPC750 processor hardware simulator and ARINC653 operating system environment.