基于四极质谱交变电场和静电场中离子运动轨迹对离子源、质量分析器和离子检测器的物理参数及几何结构尺寸进行设计，研制了宽量程四极质谱计，其物理部分核心质量为2.05 kg，体积为（315×145×60） mm³，仪器功耗为86 W，并对质谱计的质量范围、灵敏度等核心性能指标开展实验研究。结果表明，该质谱计的质量范围为2~614 u，采用氩气测试其他性能，法拉第和倍增器的检测灵敏度分别为2.62×10^-6、13 A/Pa，不同质量段50%峰高处的分辨能力分别为0.95 u（m/z 2）、0.72 u（m/z 40）、0.78 u（m/z 132）和1.32 u（m/z 614），线性工作压力上限为1.39×10^-3Pa，仪器在4 h内的信号强度稳定性为2.6%，8 h内的质量轴稳定性为±0.1 u。该质谱计有望应用于空间探测，军事技术，食品安全等领域。

A low power RF amplifier circuit for ion trap applications is presented and described. The amplifier is based on a class-D half-bridge amplifier with a voltage mirror driver. The RF amplifier is composed of an RF class-D amplifier, an envelope modulator to ramp up the RF voltage during the ion analysis stage, a detector or amplitude demodulation circuit for sensing the output signal amplitude, and a feedback amplifier that linearizes the steady state output of the amplifier. The RF frequency is set by a crystal oscillator and the series resonant circuit is tuned to the oscillator frequency. The resonant circuit components have been chosen, in this case, to operate at 1 MHz. In testings, the class-D stage operated at a maximum of 78 mW at 1.1356 MHz producing 225 V peak.

The core component of a quadrupole mass spectrometer is the\n quadrupole mass filter, serving a crucial role in ion analysis. It\n operates by applying two sets of high-voltage, high-frequency\n signals with equal amplitude and opposing phases through the radio\n frequency power supply, capitalizing on variations in the electric\n field and differences in mass-to-charge ratios to separate incoming\n ions. This study leverages direct digital frequency synthesis\n technology and multi-stage voltage amplification techniques to\n design a tailored radio frequency power supply for quadrupole mass\n spectrometers with a broad mass range. Practical testing\n demonstrates that this power supply generates radio frequency\n high-voltage signals with a peak-to-peak voltage ranging from\n 2.210 V to 4.220 kV at a resonant frequency of 1.240 MHz,\n facilitating the separation of ions with distinct m/z values. Furthermore, the radio frequency power supply is integrated\n into a Self-developed quadrupole mass spectrometer, enabling an\n assessment of the mass range, resolution, stability of the\n spectrometer. The results of these assessments confirm that the\n developed power supply accommodates scanning of m/z value ions in\n the range of 1 to 1067 while maintaining an absolute resolution of\n less than m/z = 1 units and an instrument stability of 2.00% over\n four hours.and keywords.

With outstanding analytical performance and portability, miniature mass spectrometer is one of the most powerful tools for <em>in-situ</em> analysis. The miniaturization of mass spectrometers has lasted for more than ten years, during which a number of miniature mass spectrometers employing different techniques have been developed. Small-in-size, working at relatively high pressure region and capable of performing tandem mass spectrometry, ion trap is the most widely used mass analyzer in miniature mass spectrometer systems. The recent development of miniature ion trap mass spectrometer systems in the last ten years was reviewed in this paper. These instruments adopt different atmospheric pressure interfaces (APIs), which are membrane inlets (MIs), discontinuous atmospheric pressure interface (DAPI) and continuous atmospheric pressure interface (CAPI). This review emphasizes on the mini mass spectrometry (MS) system that can be handheld by one person, but not the field-able ones that are too large to be hand-portable.

印刷线路板（Printed-Circuit-Board，以下简称PCB）分压离子阱是一种主要由印刷线路板围成的新型简单电极结构的质量分析器。PCB分压离子阱的尺寸小巧、加工装配容易且成本较低，适于用作小型化离子阱质谱仪的质量分析器。为进一步提高PCB分压离子阱的分析性能，本研究对原有的PCB分压离子阱的电压施加方式与几何结构进行改进。利用计算机模拟软件SIMION和AXSIM，分析了分压离子阱的内部电场、离子运动轨迹及模拟质谱峰图。模拟中分别采用m/z 4 000、4 001和4 002离子，结果显示在射频信号（RF）分压比不变的情况下，不同的共振激光信号（AC）分压比对质量分辨率有显著的影响。随着该分压比的减小，质量分辨率得到相应的提高。当仅在中央电极施加AC信号时，可将质量分辨率提高约25%。另一方面，撤除角接地电极的新型PCB分压离子阱结构的性能较原有PCB分压离子阱的性能更优，对于m/z 4 001离子，其质量分辨率可以达到10 325。该结果可为进一步的实验提供理论基础。